The arrests were "aimed at dismantling the Sinaloa Cartel, one of the world's most violent and powerful drug cartels, responsible for flooding the United States with fentanyl, methamphetamine, cocaine, and heroin," according to the DEA.
Brian M. Clark, special agent in charge of the Los Angeles Field Division, said that while the numbers reflect a one-week snapshot, the efforts to combat the cartel persist year-round.
ABC News' Luke Barr contributed to this report.